(The better the model, the more farfetched the loopholes are.) If you crave the certainty of a real "proof," the final word as it were, then you had better stick to mathematics or logic!
Those are the only arenas where absolute proof plays any serious role.
I've just read that eggs should not be stored in a rack on the back of a fridge door, the exact place where most fridge manufacturers put the egg rack.
Deep truths are seldom grasped whole; early models are often flawed in some of their particulars.
Facts successfully explained do carry weight and cannot be ignored; facts that don't fit are not necessarily fatal to the central ideas behind a hypothesis.
Good scientific judgment is the art of weighing all these variables and properly evaluating the big picture.
This magic bullet mentality, the tendency to rely on a single, isolated argument to win all the chips, has gotten creationists into more trouble than possibly anything else.
Unfortunately, Mother Nature does not give little, gold ribbons to certify the accuracy of our proofs!