It’s an analysis of the efficient market hypothesis and how it relates to the idea of low-hanging fruit.
It’s a self-conscious defense of the author’s own arrogance. If the world was created by the Invisible Hand, who is good, how did it come to contain so much that is evil?
But winners will probably be people with access to new ground that hasn’t already been covered by other -seekers.
There are dozens of government bodies, private institutions, and universities that could do this kind of thing if they wanted. So “science is broken” seems like the same kind of statement as “a bill has been on the floor of Grand Central Station for a week and nobody has picked it up”. Or: suppose you thought that health care is inefficient and costs way too much.
But if this were true, some entrepreneur could start a new hospital / clinic / whatever that delivered health care at lower prices and with higher profit margins.
For example: Eliezer’s wife Brienne had Seasonal Affective Disorder.
The consensus treatment for SAD is “light boxes”, very bright lamps that mimic sunshine and make winter feel more like summer.